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Naringenin 98% (Citrus Flavonoid) - Premium Antioxidant & Metabolic Support from Natural Citrus Extract
Naringenin 98% is a high-purity dihydroflavonoid compound primarily derived from grapefruit and citrus peels. As the dominant flavanone in citrus fruits 1, it delivers potent bioactive benefits validated by scientific research.
Product Name :
NaringeninCAS No. :
480-41-1Appearance :
Off white powderSpecification :
98%CAS: 480-41-1
Molecular Formula: C??H??O?
Molecular Weight: 272.25 g/mol
Appearance: Pale yellow crystalline powder/Off-white powder
Multitarget Antioxidant & Metabolic Regulator
≥98% Purity (HPLC-PDA/MS validated)
Mitochondrial Protector: Reduces ROS by 78% at 50 μM in HepG2 cells via Nrf2/ARE pathway activation.
Glucose Sensitizer: Enhances insulin-dependent glucose uptake by 3.2× in adipocytes (EC??: 12.4 μM).
1. Metabolic Health
NAFLD Reversal: 100 mg/kg/day reduces liver triglycerides by 52% via AMPK/SREBP-1c suppression.
Insulin Resistance: Lowers HOMA-IR by 41% in T2D rodent models.
2. Cardiovascular Protection
Endothelial Function: 10 μM upregulates eNOS (↑89%) and inhibits VCAM-1 in HUVECs.
Atherosclerosis: 50 mg/kg reduces aortic plaque by 63% in ApoE?/? mice.
3. Neuroprotection
Alzheimer’s Models: 25 μM decreases Aβ?? production by 57% through BACE1 inhibition.
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-DAD, λmax 290 nm) |
| Source | Citrus paradisi peel (organic, Florida) |
| Melting Point | 251-253°C |
| Solubility | DMSO (100 mg/mL), ethanol (40 mg/mL); insoluble in H?O |
| Storage | 15-25°C in opaque containers (48-month stability) |
| Key Impurities | Naringin ≤0.5% (HPLC-controlled) |
| Certifications | ISO 9001, GRAS Notice 1253 |
Nutraceutical Formulations
Metabolic Health: 250-500 mg capsules in diabetic supplements (clinical dose).
Liver Detox Blends: 10% inclusion in artichoke/silymarin complexes (ALT ↓48%).
Functional Foods & Beverages
Antioxidant Fortification: 0.1-0.5% in sports drinks (ORAC 15,200 μmol TE/g).
Stable Emulsions: β-cyclodextrin complexes for clear beverages (shelf-life >18mo).
Cosmeceuticals
1-3% serums inhibit MMP-1 (82%) and UV-induced collagen loss.
1. Green Extraction Tech
Subcritical Water Extraction:
Purity: 96.5% yield
Zero organic solvents
Energy consumption ↓40% vs. ethanol
2. Polymorph Control
Needle Crystals (β-form):
Length: 100-300 μm (bioavailability marker)
Bulk density: 0.45 g/cm³ (optimal for encapsulation)
3. Global Compliance
Dossiers ready for:
FDA Dietary Supplement Ingredient
EFSA Novel Food Application
China NHC Registration
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 500 g | Double aluminum foil bag + zip | 24 months |
| 1 kg | Pharma HDPE drum + desiccant | 24 months |
| 5 kg | Vacuum-sealed steel canister | 24 months* |
| 10 kg | Nitrogen-flushed fiber drum | 24 months* |
| 25 kg | UN-certified composite drum | 24 months* |
*At 15-25°C, RH <40%; ICH Q1A(R2) validated
Q: How to validate AMPK activation?
A: Batch-specific Western blot reports (p-AMPK/AMPK ratio) included.
Q: Solubility for beverage applications?
A: Use γ-cyclodextrin inclusion (solubility ↑ to 35 mg/mL in water).
Q: Compatibility with high-temperature processing?
A: Stable ≤140°C; add 0.1% ascorbyl palmitate for oxidation protection.
Toxicity: LD?? (oral, rat) >5000 mg/kg; non-genotoxic (OECD 471).
Allergen-Free: Certified gluten/dairy/nut-free.
Heavy Metals: As <0.1ppm, Pb <0.2ppm (ICP-MS per USP <232>).
*Data sources: J. Nutr. Biochem. 2021; 92: 108618; Free Radic. Biol. Med. 2022; 178: 246-258.*
| Weight | Packing Method | Delivery | Time |
|---|---|---|---|
| <5 kg | Foil bags in cartons | DHL/FedEx | 3-7 days |
| 5-25 kg | Sealed HDPE drums | Air Freight | 5-10 days |
| >25 kg | UN fiber drums + palletized | Sea Freight | 15-45 days |
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