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Bulk Calycosin-7-O-β-D-glucoside | Astragalus Extract

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Bulk Calycosin-7-O-β-D-glucoside | Astragalus Extract

Bulk Calycosin-7-O-β-D-glucoside | Astragalus Extract

Calycosin-7-O-β-D-glucoside (CAS: 20633-67-4) is a bioactive isoflavone glycoside primarily derived from Astragalus membranaceus roots, widely used in pharmaceutical research and nutraceutical development. With molecular formula C??H??O?? (MW: 446.4), this compound demonstrates significant antioxidant and anti-inflammatory properties.

  • Product Name :

    Calycosin-7-O-β-D-glucopyranoside
  • CAS No. :

    20633-67-4
  • Appearance :

    Fine White Powder
  • Specification :

    98%

?? Calycosin-7-O-β-D-glucoside

Synonyms: Calycosin 7-glucoside, Calycosin-7-O-β-D-glucopyranoside
CAS No.: 20633-67-4
Molecular Formula: C??H??O??
Molecular Weight: 446.40 g/mol
Botanical Source: Astragalus membranaceus (Huangqi) root extract


?? Value Proposition

? Dual-Target Bioactivity: Estrogenic Modulation + Anti-Inflammation

  • Selective ERβ Agonist: Binds to estrogen receptor beta (Ki = 0.38 μM), alleviating menopausal symptoms without uterine stimulation .

  • NF-κB Pathway Inhibitor: Reduces pro-inflammatory cytokines (IL-6/TNF-α ↓45%) in macrophage models .


?? Technical Specifications

Parameter Detail
Purity ≥98% (HPLC-DAD)
Appearance Off-white crystalline powder
Solubility Soluble in DMSO, methanol; Sparingly soluble in water (0.5 mg/mL)
Storage -20°C in amber glass vial, under nitrogen
Shelf Life 24 months (accelerated stability confirmed)
Key Physicochemical Properties • Melting Point: 228-230°C • Log P: 1.82 ±0.05

?? Clinically Validated Actions

  1. Menopausal Health

    • Efficacy: Reduces hot flash frequency by 52% (vs. placebo 18%) in 8-week trial (40 mg/day) .

    • Safety: No endometrial hyperplasia risk (ERα/ERβ selectivity ratio >12) .

  2. Cardiovascular Protection

    • Vasodilation: Enhances NO production by 80% in HUVECs, improving endothelial function .

    • Antioxidant: Scavenges •OH radicals (IC?? = 7.4 μM), preventing LDL oxidation .

  3. Dermatological Benefits

    • Collagen Synthesis: Upregulates COL1A1 expression by 3.2-fold in fibroblasts .

    • UV Barrier: Suppresses MMP-1 by 67% in UV-irradiated skin models .


?? Industry Applications

Sector Formulation Examples
Pharmaceuticals - Menopause relief capsules (20-60 mg/day)
- Cardioprotective injectables (with phospholipid complex)
Cosmeceuticals - Anti-redness serums (0.2-1% w/w)
- Collagen-boosting creams
Nutraceuticals - Women's health supplements (blended with black cohosh)
- Vascular support functional beverages

?? Competitive Advantages

?? Advanced Extraction Technology

  • Chromatographic Purification: Multi-step HPLC (C18 column) yielding >99% peak area purity .

  • Impurity Control: Astragaloside IV <0.5%, heavy metals <0.1 ppm (ICP-MS verified) .

?? Sustainable Sourcing & Traceability

  • Origin: Cultivated in GAP-certified Astragalus farms (Shanxi, China) with blockchain traceability .

  • Extraction: Ethanol/water (70:30) low-temperature extraction, preserving glycoside integrity .

?? Certifications & Compliance

  • ISO 9001:2015, ISO 17025 (CNAS-CL01 testing lab)

  • Full Dossier: COA (with chromatogram), SDS, Non-GMO Declaration, Allergen Statement


?? Packaging & Logistics

Quantity Primary Packaging Shipping Conditions
50mg–1g Amber glass vial + argon gas Cold chain (2-8°C)
1g–50g Vacuum foil bag in desiccator Dry ice
>50g HDPE drum with oxygen absorber -20°C freezer

? FAQ

Q: Is batch-specific stability data available?
A: Yes, each COA includes 24-month accelerated stability data (ICH Q1A guidelines) for humidity/light/temperature.

Q: Can you provide water-soluble formulations?
A: We offer:

  • Hydroxypropyl-β-cyclodextrin complexes (water solubility >20 mg/mL)

  • Liposomal nanoemulsions for enhanced bioavailability

Q: Minimum order for R&D samples?
A: 50mg (≥98%), shipped with full characterization data (NMR, MS, HPLC).


?? Why Partner With Us?

  • Bioactivity Guarantee: Lot-to-lot consistency verified by ERβ binding assay (EC?? = 0.42±0.07 μM).

  • End-to-End Solutions: From bulk powder to ready-to-use formulations (gels, capsules, liquids).

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Calycosin-7-O-&beta;-D-glucoside (CAS: 20633-67-4)&nbsp;is a bioactive isoflavone glycoside primarily derived from&nbsp;Astragalus membranaceus&nbsp;roots, widely used in pharmaceutical research and nutraceutical development. With molecular formula&nbsp;C??H??O??&nbsp;(MW: 446.4), this compound demonstrates significant antioxidant and anti-inflammatory properties.

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